Hairul Islam Mohamed Ibrahim

Research scientist and Assistant professor with 10+ years of experiences in the level of undergraduate and postgraduate in both academic and research organizations. Supervised master thesis and contemporary role as principal investigator as well as editor in multiple research articles. Published over 85 research paper and received 4 product oriented US patents in the field of biomedical engineering.

PUBLICATION SUMMARY SINCE 2010 - (Cumulative Impact fact = 138.52) Citations: 1161; h-index: 22 i10-index: 30. US PATENT APPROVED AND FILED: REVIEW ARTICLES PUBLISHED BOOK CHAPTER: Technology” organized by Madha engineering College, chennai, ISBN: 978-81- 907494-8-0: 120-125. PUBLICATION: GENE SEQUENCE SUBMITTED TO NCBI DATABASE TRAINING AND WORKSHOP ORGANIZED

Proposed and received top notch research grant from King salman disability centre for moelcular research at 2022 and 2023.

RESEARCH INTEREST: Probiotic selection and evaluation, Host-Pathogen interactions, Molecular analysis of food allergen susceptibility, Antibiotic resistant analysis and development of antimicrobials, Microbiome in intestinal environment, miRNA and biomarker development.

REASEARCH ARTICLES PUBLISHED (from 2020)

1. Khalifa, A.; Ibrahim, H.I.M.; Sheikh, A.; Khalil, H.E. Probiotic-Fermented Camel Milk Attenuates Neurodegenerative Symptoms via SOX5/miR-218 Axis Orchestration in Mouse Models. Pharmaceuticals 2023, 16, 357. https://doi.org/10.3390/ph16030357.

2. Ashraf K, Hairul Islam MI, Enterococcus faecium from chicken feces improves chicken immune response and alleviates Salmonella infections: a pilot study, Journal of Animal Science, 2023;, skad016, https://doi.org/10.1093/jas/skad016

3. Ibrahim, H.I.M.; Sheikh, A.; Khalil, H.E.; Khalifa, A. Bacillus amyloliquifaciens-Supplemented Camel Milk Suppresses Neuroinflammation of Autoimmune Encephalomyelitis in a Mouse Model by Regulating Inflammatory Markers. Nutrients 2023, 15, 550. https://doi.org/10.3390/nu15030550.

4. Almansour, Z.H.; Ibrahim, H.-I.M.; Hamad, R.S.; Abd El-Moaty, H.I. Phenolic-Compound-Rich Opuntia littoralis Ethyl Acetate Extract Relaxes Arthritic Symptoms in Collagen-Induced Mice Model via Bone Morphogenic Markers. Nutrients 2022, 14, 5366. https://doi.org/10.3390/nu14245366.

5. Ahmed, E.A.; Abu Zahra, H.; Ammar, R.B.; Mohamed, M.E.; Ibrahim, H.-I.M. Beta-Caryophyllene Enhances the Anti-Tumor Activity of Cisplatin in Lung Cancer Cell Lines through Regulating Cell Cycle and Apoptosis Signaling Molecules. Molecules 2022, 27, 8354. https://doi.org/10.3390/molecules27238354.

6. Kaliyamoorthy, V., Jacop, J.P., Thirugnanasambantham, K. et al. The synergic impact of lignin and Lactobacillus plantarum on DSS-induced colitis model via regulating CD44 and miR 199a alliance. World J Microbiol Biotechnol 38, 233 (2022). https://doi.org/10.1007/s11274-022-03424-z.

7. Ibrahim, HIM.; Sayed, AA.; Ahmed, Abdel Naser A.; Ahmed, EA. Pinocembrin Ameliorates Neuronal Cell Death by Regulating Autoimmune Signals. Pakistan Journal of Zoology . Vol. 54 Issue 6, p2639-2649. 11p.

8. Khalil, H.E.; Abdelwahab, M.F.; Ibrahim, H.-I.M.; AlYahya, K.A.; Altaweel, A.A.; Alasoom, A.J.; Burshed, H.A.; Alshawush, M.M.; Waz, S. Cichoriin, a Biocoumarin, Mitigates Oxidative Stress and Associated Adverse Dysfunctions on High-Fat Diet-Induced Obesity in Rats. Life 2022, 12, 1731. https://doi.org/10.3390/life12111731

9. Khalil, H.E.; Abdelwahab, M.F.; Ibrahim, H.-I.M.; AlYahya, K.A.; Mohamed, A.A.; Radwan, A.S.; Waz, S. Mechanistic Insights into the Ameliorative Effect of Cichoriin on Diabetic Rats—Assisted with an In Silico Approach. Molecules 2022, 27, 7192. https://doi.org/10.3390/molecules27217192.

10. Ibrahim, H.-I.M.; Thangavelu, M.; Khalifa, A. Honey-Propolis-Engineered Collagen Peptides as Promising Wound-Healing Matrix in Mouse Model. Molecules 2022, 27, 7090. https://doi.org/10.3390/molecules27207090

11. Joseph B, MP Soosaimanickam, C Emmanuel, T Krishnaraj, A Sheikh, Hairul Islam. 8-Hydroxyquinoline a natural chelating agent from Streptomyces spp. inhibits A549 lung cancer cell lines via BCL2/STAT3 regulating pathways. World Journal of Microbiology and Biotechnology 38 (10), 1-12.

12. Hany EK, Miada F. Abdelwahab, Promise Madu Emeka, Lorina, Hairul Islam. Brassica oleracea L. var. botrytis Leaf Extract Alleviates Gentamicin[1]Induced Hepatorenal Injury in Rats—Possible Modulation of IL-1 and NF-?B Activity Assisted. Life 12, 1370.

13. Hairul Islam MI, Mayaddah Al Kuwaiti, Emad A. Ahmed. Atropine Is a Suppressor of Epithelial–Mesenchymal Transition (EMT) That Reduces Stemness in Drug-Resistant Breast Cancer Cells. International Journal of Molecular sciences 23, 9849.

14. A Negm, M Gouda, HIM Ibrahim. Carboxymethyl Cellulose/Zn-Organic Framework Down-Regulates Proliferation and Up-Regulates Apoptosis and DNA Damage in Colon and Lung Cancer Cell Lines. Polymers 14 (10), 2022.

15. A Khalifa, A Sheikh, HIM Ibrahim. Bacillus amyloliquefaciens Enriched Camel Milk Attenuated Colitis Symptoms in Mice Model. Nutrients 14 (9), 1967.

16. Rajendran, B., Manickam, V., Tamizhselvi, R., PrabhuDass, J.F., Iyer, S.K., Thirugnanasambantham, K. and Ibrahim, H.-I.M. Azabicyclononane derivative downregulates the P38 MAP-kinase pathway in colon cancer through apoptosis . Chemical Biology Letters. 9, 4 (Jul. 2022), 369.

17. S Khattab, F El Sherif, M AlDayel, YK Yap, A Meligy, HIM Ibrahim. Silicon dioxide and silver nanoparticles elicit antimicrobial secondary metabolites while enhancing growth and multiplication of Lavandula officinalis in-vitro plantlets. Plant Cell, Tissue and Organ Culture (PCTOC) 149 (1), 411-421.

18. M Gouda, HIM Ibrahim, A Negm. Chitosan containing nano Zn-organic framework: Synthesis, characterization and biological activity. Polymers 14 (7), 1276

19. HE Khalil, HIM Ibrahim, KA El-Fass, SH Akrawi, MA Morsy. Orientin Alleviates Liver Inflammation via Downregulation of ZEB-2/PTEN Markers—Hepatic Stellate Cells Approach. Applied Sciences, 2022, 12 (5), 2725

20. Hairul‑Islam MI, Emad A. Ahmed, Abdullah M. Alzahrani. Swertiamarin ameliorates inflammation and oxidative damage in autoimmune encephalomyelitis mouse model, Applied biological chemistry, 2022, 65 (19), 1-13

21. HE Khalil, HIM Ibrahim, EA Ahmed, PM Emeka, IA Alhaider. Orientin, a Bio[1]Flavonoid from Trigonella hamosa L., Regulates COX-2/PGE-2 in A549 Cell Lines via miR-26b and miR-146a. Pharmaceuticals, 2022, 15 (2), 154.

22. P Saravana Kumar, G Nattudurai, VI. Hairul Islam & S. Ignacimuthu. The effects of some essential oils on Alternaria alternata, a post‑harvest phyto‑pathogenic fungus in wheat by disrupting ergosterol biosynthesis. Phytoparasitica, 2022, https://rdcu.be/cF1Fi.

23. Hairul Islam M I, A AlZahrani, H Hanieh, EA Ahmed. MicroRNA-7188-5p and miR-7235 regulates Multiple sclerosis in an experimental mouse model. Molecular Immunology. 2021. 139, 157-167.

24. H Hanieh, HIM Ibrahim, M Mohammed, OI Alwassil, MH Abukhalil. Activation of aryl hydrocarbon receptor signaling by gallic acid suppresses progression of human breast cancer in vitro and in vivo. Phytomedicine, 2021. 153817.

25. Promise Madu Emeka, Hairul Islam M. Ibrahim. Protective effects of lutein against vancomycin-induced acute renal injury via upregulation of Nrf2- and PPARγ-induced NF-κB. The Korean Journal of Physiology & Pharmacology. 2021.

26. Hany Ezzat K, Hossam M Darrag, Hairul-Islam M.I., Promise M Emeka, Lorina I Badger-Emeka, Katsuyoshi Matsunami, Tamer M Shehata, Heba S Elsewedy Date Palm Extract (Phoenix dactylifera) PEGylated Nanoemulsion: Development, Optimization and Cytotoxicity Evaluation. Plants, 2021, 735.

27. Emad A Ahmed, Hairul-Islam M Ibrahim, Hany Ezzat Khalil. Pinocembrin Reduces Arthritic Symptoms in Mouse Model via Targeting Sox4 Signaling Molecules. J. Med Food. 2021, 281-290.

28. Hassan H. Hammud, Gregory J. McManus, Michael J. Zaworotko, Rola N. Tabesh, Hairul Islam M. Ibrahim, Khurshid Ayub, Ralf Ludwig. The co‑crystal of copper(II) phenanthroline chloride complex hydrate with p‑aminobenzoic acid: structure, cytotoxicity, thermal analysis, and DFT calculation. Monatshefte für Chemie - Chemical Monthly, 2021, 323-336.

29. Faisal Almathen and Hairul Islam M Ibrahim, Abdullah Sheikh. Expression of the Tyrosinase Gene in Different Dromedary Camels of Saudi Arabia. pakistan journal of zoology, 2021, 1-7.

30. Hairul Islam M Ibrahim, Mohammad Bani Ismail, Rebai Ben Ammar, Emad A Ahmed. Thidiazuron suppresses breast cancer via targeting miR-132 and dysregulation of the PI3K–Akt signaling pathway mediated by the miR-202-5p–PTEN axis. Biochemistry and Cell Biology, 2021, 1-11.

31. Lorina I Badger-Emeka, Promise Madu Emeka, Hairul Islam M Ibrahim. A Molecular Insight into the Synergistic Mechanism of Nigella sativa (Black Cumin) with β-Lactam Antibiotics against Clinical Isolates of Methicillin-Resistant Staphylococcus. Applied Sciences, 2021, 3206.

Patent approved and filed

1. Inventors list- Dr. Hairul Islam & Dr. Ashraf khalifa. US patent Docket No: 33101.09U.

Title of invention: fermented camel milk with propolis-engineered probiotic for treating adverse bowel disorders.

2. Inventors list- Dr. Hairul Islam & Dr. Ashraf khalifa. US patent Docket No: 33101.05U.

Title of invention: Composition of treating irritable bowel syndrome.

3. Inventors list- Dr. Hairul Islam & Dr. Thirugnansambantham, Dr. Hany ezzat khalil. US patent Docket No: 32087.97U. Title of invention: Rectal gel loaded with Date palm phenolics and vanillic acid‎.

4. Inventors list- Dr. Hairul Islam, Dr. hany ezzat Khalil & Dr. Muthukumar T. US patent Docket No: 32087.96U. Title of invention: Reinforced porous collagen sheet for wound healing ailment‎.

Review publicationBook chapter and proceedings

1. Durairaj, S., Hairul Islam, V.I., Thirugnanasambantham, K., Saravanan, S. 2014. Relevence of miR-21 in HIV and Non-HIV related Lymphomas. Tumor Biology (6th May- DOI 10.1007/s13277-014-2068-9).

2. Durairaj, S., Hairul Islam, V.I., Thirugnanasambantham, K., Saravanan, S. Sequencing approaches in Cancer Treatment. Cell Proliferation (Doi: 10.1111/cpr.12124).

3. Krishnaraj Thirugnanasambantham, Sekar Durairaj, Subramanian Saravanan, Kulandaivelu Karikalan, Senguttuvan Muralidaran, Villianur Ibrahim Hairul Islam. 2014. Role of Ethylene Response Transcription Factor (ERF) and Its Regulation in Response to Stress Encountered by Plants. Plant Mol Biol Rep. DOI 10.1007/s11105- 014-0799-9.

1. K. Thirugnanasambantham, V.I. Hairul Islam, S. Saravanan, V. Senthil Kumar,

G. Ashok, M. Chellappandian. Role of miRNA in Multiple Sclerosis. CRC Press, MicroRNA-2018.

2. S. Arokiyaraj, M. Saravanan, R. Bharanidharan, V. I. Hairul Islam, M. Bououdina, S Vincent. Green Synthesis of Metallic Nanoparticles Using Plant Compounds and Their Applications: Metallic Nanoparticles Synthesis Using Plants. IGI global. Emerging Research on Bioinspired Materials Engineering, 2016.

RESEARCH PUBLICATION IN CONFERENCE AND PROCEEDINGS

1. V.I. Hairul Islam, S. Saravanan, R. Chandrika and Thirugnanasambantham K (2014). Anti-infective and biocompatible endophytic Vibrio alginolyticus isolated from Andrographis paniculata (Brum.f.) Wall. exNeel. P.31. In: Abstracts. MAHER National Summit on Current Research in Science organized by Department of Microbiology, Meenakshi Ammal Dental College Chennai – 600 095 India.

2. Hairul Islam V.I, Thirugnanasambantham K and Saravanan S. 2012. A novel approach for isolation and characterization of biostatic probiotics isolated from healthy infant. In Proceedings of 2nd National Conference on “Transfigures in Bioscience and

3. Hairul Islam V.I, Saravanan S, Thirugnanasambantham K and Ignacimuthu S. 2012. Cytokine regulation in fungal infected keratinocytes by influence of Microbial proteins. In Proceedings of National Conference on Recent Trends in Industrial Pharmacognosy, 2012. Pp 16-17. International Journal of Pharma and Bio Sciences ISSN 0975 – 6299.

Gene Bank submission

1. Hairul Islam, V.I. Bacillus cereus strain EPB-8 16S ribosomal RNA gene, partial sequence GenBank: HQ157567.

2. Hairul Islam, V.I. Micromonospora marina strain EHA-8 16S ribosomal RNA gene, partial sequence GenBank: HQ127630.

3. Hairul Islam V.I. Actinomadura sp. EHA-2 16S ribosomal RNA gene, partial sequence GenBank: GU998793.

4. Hairul Islam V.I. Streptomyces rochei 16s sequence Genbank - HQ127628

5. Hairul Islam V.I. Bacillus amyloliquefaciens strain PBT-3 16s sequence. Genbank- JF836079

6. Hairul Islam, V.I. Bacillus cereus strain EPB-8 fibrinogen-binding protein gene complete CDS. Genbank: Protein ID- AFZ62656.1 and Gene ID: KC012948.

7. Hairul Islam, V.I. Proteolytic bacteria from Himalayan soil samples. Genbank -: JQ768222 - JQ768231.

TRAINING AND WORKSHOP ORGANIZED:

Organized and demonstrate the workshop in “miRNA Biology, Identification and applications” in Pondicherry centre for Biological sciences, India. 13-15 May-2014.

Organized and demonstrate the workshop in “Real Time PCR application and Diagnostics” in Meenakshi ammal dental college, India. 14-17 October-2012.

Organized and demonstrate “Animal cell culture techniques and toxicology” in Biozone research technologies, Chennai, India. 22- 30 March 2011.

Delivered lecture and demonstrate “Cell culture maintenance and applications” in Meenakshi ammal dental college, Chennai. India. 26-28 August-2010.

OTHER DEGREES and DIPLOMAS:

Diploma in Computer Hardware Engineering at Trilogi Technologies, Pondicherry, India 2004.