Nisreen Al-Moghrabi

A senior scientist in cancer epigenetics specializing in studying epigenetic biomarkers in peripheral white blood cells to predict cancer risk. I'm also focusing on finding natural epigenetic therapeutic chemicals to cure and prevent cancer. Determined and well-rounded individual with more than 25 years working as a research scientist. Sharp and focused professional offering skills in cancer research. Detail-oriented team player with strong organizational skills. Ability to handle multiple projects simultaneously with a high degree of accuracy.

• Epigenetic effect of PAC on Breast Cancer cells, 2220027, 2022
• The molecular significance of constitutive MGMT epimutation in cancer-free females, 2210004, 2021
• The effect of methylated BRCA1 promoter on the expression of microrna-155 in breast cancer cell lines, 2190018, 2018
• Screening healthy Saudi women for methylated BRCA1 promoter in peripheral blood cells, 2170017, 2017
• Screening for methylated BRCA1 in couples before, during and after pregnancy and in the newborns, 2200004, 2020
• BRCA1 epimutation in newly born female babies: The molecular significance and inheritance, 2141146, 2015
• Epigenetic effect of curcumin on breast cancer cells, 2150020, 2015
• BRCA1 epimutation and breast cancer predisposition, 2100022, 2010
• The methylation status of the BRCA1 promoter in Saudi Breast Cancer Females, 2100011, 2010
• The methylation status of the MGMT promoter in Gliomas from Saudi patients, 2080024, 2008
• Expression of γ-Synuclein and its role in ovarian cancer in Saudi’s female patients, 2050041, 2004

• Molecular and clinical markers of response and toxicity in patients with metastatic colorectal cancer treated with triplex therapy, 2160002, 2016
• Identification of the Mutational Spectrum and Frequencies of BRCA1 and BRCA2 genes in Saudi Breast and Ovarian Cancer Populations, 2013
• The potential role of Il-6 in the cross-talk between breast carcinomas and their Stromal fibroblasts, 2013

• BRCA1 epimutation and breast cancer predisposition, King Abdulaziz City for Science and Technology (KACST), 1211000, SAR
• BRCA1 epimutation in newly born female babies: The molecular significance and inheritance, King Abdulaziz City for Science and Technology (KACST), 1364250, SAR

• Supervisor, M.Sc., King Saud University, 2021, 2022, The molecular significance of methylated MGMT promoter in white blood cells of cancer-free females
• Undergraduate research project, Bachelor of Science, Al Faisal University, 2019, 2020, The epigenetic effect of curcumin on the levels of miR-155 in breast cancer cell lines
• Supervisor, M.Sc., King Saud University, 2018, 2020, Identification of molecular biomarkers for the early prediction of breast and ovarian cancers in cancer-free BRCA1-methylated carriers
• Supervisor, M.Sc., Al Faisal University, 2016, 2017, Epigenetic effect of curcumin in Breast Cancer cells
• Supervisor, M.Sc., King Saud University, 2014, 2014, Studying the effect of cancer cells and interleukin-6 on gene methylation in breast stromal fibroblasts
• Supervisor, M.Sc., Girls College of Education, 2005

I trained 12 trainees during the period from 2015 until 2022.

• Cancer Investigation: LCNV-2022-OR-0749, 2022
• Bioengineered: No. KBIE-2022-3479, 2022
• Oncology letters OL-23129-259263-03, 2022
• PLOS ONE, Dec, 2021
• BMC Cancer: 39f2b7a2-f91a-4203-b2f1-492a21023bee, 2020
• JTUMED-D-20-0086: Journal of Taibah University Medical Sciences, 2020
• PLOS ONE, 2019
• Epigenetics Methods, 2019
• Journal of Taibah University Medical Sciences, 2017
• Medical Science Monitor, 2016
• PLOS ONE, 2016
• PLOS ONE, 2013
• Cancer Epidemiology, 2012

• INTERNATIONAL CONFERENCE ON MOLECULAR ONCOLOGY AND PRECISION MEDICINE, November 16-18, 2023, KFSHRC
• THE RESEARCH & INNOVATION SEMINAR SERIES, May 15, 2023
• THE ONCOLOGY CENTRE & RESEARCH CENTRE COLLABORATIVE MEETING, 2023, KFSHRC
• THE ONCOLOGY CENTRE & RESEARCH CENTRE COLLABORATIVE MEETING, 2022, KFSHRC
• ADVANCES ON BREAST CANCER RESEARCH: TOWARDS PRECISION THERAPY, November 7-8, 2018, KFSHRC
• RESEARCH CENTRE ANNUAL REPORT, April 19-20, 2017
• MOLECULAR ONCOLOGY STATE OF THE ART TECHNOLOGIES, March 2015, KFSHRC
• Mini-Symposium (INVASIVE BREAST CANCER: NEW MOLECULAR INSIGHTS AND TRANSLATIONAL POTENTIALS), January 8, 2014, KFSHRC
• RESEARCH CENTRE ANNUAL REPORT, April 16, 2013
• THE TWENTY FIRST INTERNATIONAL CONFERENCES ON YEAST GENETICS AND MOLECULAR BIOLOGY, July 7-12, 2003, Gothenburg, Sweden
• THE 10TH INTERNATIONAL SYMPOSIUM ON MICROSOMES AND DRUG OXIDATION, July 18-21, 1994, Toronto, Canada

• Al Jazeera, 16855, November 21, 2018
• Interview for THE BUSINESS CLINIC SECTION OF THE BUSINESS MEN JOURNAL, 63-7Th, September 10, 2010

• Epigenetics
• Molecular Biology

• Al-Moghrabi N Al-Showimi, M., Alqahtani, A., Almalik, O., Alhusaini, H., Almalki, G., Saad, A., Alsunayi, E., Constitutional BRCA1 and MGMT Methylation Are Significant Risk Factors for Triple-Negative Breast Cancer and High-Grade Serous Ovarian Cancer in Saudi Women, Int. J. Mol. Sci., 25, 3108, 2024, https://doi.org/10.3390/ijms25063108
• Al-Showimi, M., Al-Yousef, N., AlOtai, L., MicroRNA-155-5p, Reduced by Curcumin-Re-Expressed Hypermethylated BRCA1, Is a Molecular Biomarker for Cancer Risk in BRCA1-methylation Carriers, Int. J. Mol. Sci., 24, 9021, 2023, https://doi.org/10.3390/ijms24109021
• Al-Showimi M, Al-Yousef N, Alharbi W, Alkhezayem S, Almalik O, Alhusaini H, Alghamdi A, Al-Moghrabi N
• MicroRNA-126 expression in the peripheral white blood cells of patients with breast and ovarian cancer is a potential biomarker for the early prediction of cancer risk in the carriers of methylated BRCA1, Oncol Lett., 24, 276, 2022, 10.3892/ol.2022.13396
• Al-Kharashi LA, Bakheet T, AlHarbi WA, Al-Moghrabi N, Aboussekhra A., Eugenol modulates genomic methylation and inactivates breast cancer-associated fibroblasts through E2F1-dependent downregulation of DNMT1/DNMT3A, Mol Carcinog., 60, 11, 784-795, 2021, 10.1002/mc.23344
• Nujoud Al-Yousef1, Zakia Shinwari1, Bushra A1-Shahrani1, Maram Al-Showimi1, Al-Moghrabi N
• Curcumin induces re‑expression of BRCA1 and suppression of γ synuclein by modulating DNA promoter methylation in breast cancer cell lines, Oncology Reports, 2020, https://doi.org/10.3892/or.2020.7473
• Al-Showimi M, Al-Yousef N, Al-Shahrani B, Karakas B, Alghofaili L, et al., Methylation of BRCA1 and MGMT genes in white blood cells are transmitted from mothers to daughters, Clin Epigenetics, 10, 99, 2018
• How early can breast or ovarian cancer risk be predicted? Transmission of epigenetic changes to BRCA1 and MGMT genes, On Biology Blog. BMC, Aug 9, 2018
• Al-Joharah Alhuqail, Areej Alzahrani, Hannah Almubarak, Sarah Al-Qadheeb, Lamyaa Alghofaili, Nisreen Al-Moghrabi
• Hamed Alhussaini, Ben Ho Park, Dilek Colak, Bedri Karaks, Asma Tulbah, Abdelilah Aboussekhra, High prevalence of deleterious BRCA1 and BRCA2 germline mutations in Arab breast and ovarian cancer patients, Breast Cancer Res Treat, 2018, https://doi.org/10.1007/s10549-017-4635-4
• Al-Yousef N, Al-Showimi M, et al., MicroRNA-126 is Dysregulated in Cancer-Free Females Harboring Methylated BRCA1 Promoter through Up-Regulation of DNMTs, J Clin Epigenet., 3, 1, 2017
• Al-Moghrabi NM
• BRCA1 promoter methylation in peripheral blood cells and predisposition to breast cancer, J Taibah Univ Med Sc, 12, 3, 189-193, 2017
• Allam A, Alhindi H, Al-Otaibi F, Al-Hebshi, Khalil and Al-Moghrabi
• The Response to Chemo Radiation Therapy in Unresectable Glioblastoma Multiforme Patients in Relation to MGMT Promoter Methylation Status: A Study from a Single Saudi Center, J Clin Epigenet., 3, 2, 2017
• Nisreen M. Al-Moghrabi, Ibtehaj S Al-Sharif, Abdelilah Aboussekhra, The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females, BMC Cancer, 14, 830, 2014
• Nisreen M. Al-Moghrabi, Ibtehaj S Al-Sharif, Abdelilah Aboussekhra, Methylation-related mutations in the BRCA1 promoter in peripheral blood cells from breast cancer-free female, Int J Oncol, 39, 1, 129-135, 2011
• Nisreen M. Al-Moghrabi, Ibtehaj S Al-Sharif, Abdelilah Aboussekhra, UV-induced de novo protein synthesis enhances nucleotide excision repair efficiency in a transcription-dependent manner in S. cerevisiae, DNA Repair, 2, 10, 1185-97, 2003
• Nisreen M. Al-Moghrabi, Ibtehaj S Al-Sharif, Abdelilah Aboussekhra, The Saccharomyces cerevisiae RAD9 cell cycle checkpoint gene is required for optimal repair of UV-induced pyrimidine dimers in both G1 and G2/M phases of the cell cycle, Nucleic Acids Res., 29, 9, 2020-2025, 2001
• Julian R.F.Walters, Alison Howard, Nisreen Moghrabi and Stephen Legon, VitaminD: a Pluripotent Hormone-Structural studies, molecular Endocrinology and clinical Applications, Walter de Gruter, 1994, 396-397
• Nisreen Moghrabi, The role of UV-induced de novo protein synthesis in nucleotide excision repair is transcriptional-dependent in S. cerevisiae, Abstract in the 10Th International Symposium On Microsomes and Drug Oxidation, 1994